We live in upstate NY and my wife is good for tours around New England and the Northeast, but any trips of more than a day's ride are a problem. So like Steve and Mel above, we rely on flying her to the ride destination.
In 2015 that was Big Bend NP in TX. I did the nice 4 day solo trip down there, getting into the whole Motorcycling ZEN thing picking my wife up at the Midland, TX airport. I had a great ride down there and she arrived rested, relaxed and ready to ride. She loves riding, but just simply can't do the 600-800 miles days you need to get anywhere in this great country! After a wonderful week in the Big Bend area, I put her back on the plane and headed home using a different route through the TX Hill Country, LA, and northeast from there.
We've been doing it this way since 2000, and so far I've ridden to and through 46 of the states. My retirement trip (which can't come soon enough) will be OR, WA, and Alaska! I'll fly her into WA and take a few days getting up into Alaska. Works for us. Sometimes, I pick our destination based on economical flights that I see advertised. This year might be the Smokey's or Denver, haven't decided yet.